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Zhang Lab mouse model helps researchers identify immune mechanism for Epstein-Barr virus infection surveillance

A research breakthrough reported in Cell is attributed to one of the Zhang Lab’s mouse models in a Hematology Times interview with Klaus Rajewsky, MD, Max Delbrück Center for Molecular Medicine, Germany.

“We had previously attempted to develop an animal model of LMP1 transformation of B cells,” Dr Rajewsky said. “But we had never been able to get the mice in our models to actually produce any mature B cells. The immune response against the LMP1-producing B cells was so robust that the cells were eliminated very early on.”

Dr. Zhang and his colleagues reengineered the model to lack T cells. “The mice were initially fine but succumbed within 2 to 3 months to aggressive B-cell lymphomas,” Dr Rajewsky said in the interview. “The profile mimicked very closely what we see in immunosuppressed lymphoma patients.”

Read the interview in Hematology Times.

Access the research article in Cell (Vol 184, Issue 4, pp 739-751, 17 February 2012)