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Congratulations to Il-Kyu for his new paper published in PNAS (PMID: 29311309). This work reveals the molecular mechanism by which LMP1-expressing (EBV-infected) B cells induce potent cytotoxic CD4 and CD8 T cell responses, and suggests LMP1-based approaches for rapid production of cytotoxic CD4 and CD8 T cells for cancer immunotherapy.